Comparison of reactions to human and armadillo lepromins in leprosy.
نویسندگان
چکیده
To assess the usefulness of Mycobacterium leprae-infected armadillo tissue as a substitute for human lepromas for the manufacture of lepromin, we compared skin reactions to preparations from these two sources in 115 leprosy patients. The patient sample represented all the primary clinical forms of leprosy. Lepromin derived from the armadillo (lepromin-A) provoked the same pattern of responses as human derived lepromin (lepromin-H), i.e., lepromatous patients gave the weakest reactions. Lepromin-A reactions were consistently more intense than those to lepromin-H. We conclude that lepromin-A is a promising alternative to lepromin-H and may make the worldwide distribution of a standardized skin testing reagent feasible.
منابع مشابه
Comparison in leprosy patients of Fernandex and Mitsuda reactions using human and armadillo antigens. A double-blind study.
The Mitsuda and Fernandez reactions to bacilli prepared from lesions of human patients and bacilli from infected armadillos were studied in 112 leprosy patients. It was observed that there is no substantial difference when armadillo lepromin is used instead of human lepromin except that a larger induration occurs with the use of the armadillo lepromin in a majority of cases. The number of those...
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ورودعنوان ژورنال:
- International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
دوره 43 3 شماره
صفحات -
تاریخ انتشار 1975